HPLC Purity
Agilent 1260 Infinity II
Liquid chromatograph with quaternary pump, thermostatted column compartment, and 1260 Diode Array Detector (DAD). Operated with OpenLab CDS for data acquisition and integration.
Instrumentation
Analytical Equipment
Our laboratory operates a focused analytical panel on current-generation chromatography and spectrometry platforms. All instruments are maintained on scheduled preventive maintenance contracts and qualified per IQ / OQ protocols.
LC-MS Identification
Waters Xevo TQ-S with Acquity UPLC
Triple-quadrupole mass spectrometer coupled to Acquity UPLC front-end. ESI source, positive / negative mode switching, full-scan and MRM capability. MassLynx for data processing.
GC-MS / Residual Solvents
Shimadzu GCMS-QP2020 NX
Single-quadrupole GC-MS with headspace autosampler (HS-20). Configured for ICH Q3C Class 1–3 residual solvent screening and volatile impurity profiling.
Water Content
Metrohm 915 KF Ti-Touch
Coulometric Karl Fischer titrator for low-moisture samples. Separate volumetric configuration available for samples above 5% water content.
Bacterial Endotoxins
Charles River Endosafe Kinetic-QCL Reader
Kinetic chromogenic LAL reader with heating block and automated curve fitting. Reagent lots tracked per sample with certificate reference on final COA.
Analytical Balance
Mettler Toledo XS204
Semi-micro analytical balance, 0.1 mg readability. Daily calibration verification with NIST-traceable reference weights.
Sample Preparation
Eppendorf Centrifuge 5424 R
Refrigerated benchtop microcentrifuge for sample clarification, protein precipitation, and digestion preparation workflows.